Isolation and Structure ofstaph-cAM373 Produced byStaphylococcus aureusThat Induces Conjugal Transfer ofEnterococcus faecalisPlasmid pAM373

Abstract
Enterococus faecalis plasmid pAM373 encodes a mating response to the sex pheromone, cAM373, which is secreted from pAM373-free E. faecalis. cAM373-like activity was detected in a culture filtrate of Staphylococcus aureus. The major active substance, termed staph-cAM373, was isolated, and its structure was identified as a H-Ala-IIe-Phe-IIe-Leu-Ala-Ala-OH heptapeptide.

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