Towards a mechanism-based analysis of pharmacodynamic drug?drug interactions in vivo

• 23 December 2004
• journal article
• review article
• Published by Elsevier in Pharmacology & Therapeutics
• Vol. 106  (1) , 1-18
• https://doi.org/10.1016/j.pharmthera.2004.10.014

Abstract

Keywords

• DRUG COMBINATION
• MECHANISM-BASED PHARMACODYNAMIC INTERACTION MODEL
• SYNERGY
• RESPONSE SURFACE ANALYSIS
• OPERATIONAL MODEL OF PHARMACOLOGICAL AGONISM