Active vascular capacity responses in isolated skeletal muscle

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Abstract
Perfusion pressure, blood flow, and weight were measured during step changes in arterial pressure in the isolated, pump-perfused dog tongue. Pressure changes produced alterations in blood flow and preparation weight. Changes in weight were determined to primarily reflect alterations in venous capacity. If the preparation was active, initial changes were succeededby secondary reactions that returned flow and weight to or toward their former levels. It was concluded that the secondary capacitance responses were active since: secondary capacitance reactions remained when resistance vessels reacted passively, and secondary capacitance reactions were reduced or absent when resistance vessels exhibited marked reactivity. In both instances, a lack of correlation existed between the pressure-induced alterations in venous transmural pressure and the changes in capacity. It was demonstrated that the interpretations of capacitance vessel passivity by other authors were inconsistent with their data.