Periostin as a Novel Factor Responsible for Ventricular Dilation
- 28 September 2004
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 110 (13) , 1806-1813
- https://doi.org/10.1161/01.cir.0000142607.33398.54
Abstract
Background— Periostin is highly expressed in the myocardium in patients with heart failure. However, no report has documented the function of periostin. To identify the function of periostin in the pathophysiology of heart failure, overexpression or loss of function of the periostin gene was examined by direct transfection into the rat heart. Methods and Results— Rats transfected with the periostin gene by the HVJ-liposome method showed left ventricular (LV) dilation as assessed by echocardiography, accompanied by an increase in periostin expression. Consistently significant differences were observed in LV pressure, LV end-diastolic pressure, LV dP/dtmax, and LV dP/dtmin at 6 and 12 weeks after transfection in rats transfected with the periostin gene, accompanied by a decrease in cardiac myocytes and an increase in collagen deposition. Importantly, periostin has the ability to inhibit the spreading of myocytes and the adhesion of cardiac fibroblasts with or without fibronectin. Markers of cardiac dysfunct...Keywords
This publication has 28 references indexed in Scilit:
- Severe cardiomyopathy in mice lacking dystrophin and MyoDProceedings of the National Academy of Sciences, 1999
- Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart.Journal of Clinical Investigation, 1996
- A novel X-linked gene, G4.5. is responsible for Barth syndromeNature Genetics, 1996
- A Point Mutation in the 5' Splice Site of the Dystrophin Gene First Intron Responsible for X-Linked Dilated CardiomyopathyHuman Molecular Genetics, 1996
- Cardiac myosin binding protein–C gene splice acceptor site mutation is associated with familial hypertrophic cardiomyopathyNature Genetics, 1995
- Mutations in the cardiac myosin binding protein–C gene on chromosome 11 cause familial hypertrophic cardiomyopathyNature Genetics, 1995
- α-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: A disease of the sarcomereCell, 1994
- Deletion of the Dystrophin Muscle-Promoter Region Associated with X-Linked Dilated CardiomyopathyNew England Journal of Medicine, 1993
- Effect of Enalapril on Mortality and the Development of Heart Failure in Asymptomatic Patients with Reduced Left Ventricular Ejection FractionsNew England Journal of Medicine, 1992
- A molecular basis for familial hypertrophic cardiomyopathy: A β cardiac myosin heavy chain gene missense mutationPublished by Elsevier ,1990