T Cell Subsets and Cytomegalovirus Retinitis in Human Immunodeficiency Virus‐Infected Patients
Open Access
- 1 September 1997
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 176 (3) , 790-794
- https://doi.org/10.1086/517303
Abstract
A case-control study was done to investigate the relationship between T cell subsets and cytomegalovirus (CMV) retinitis in human immunodeficiency virus (HIV)-infected subjects with or without CMV retinitis and CD4/ cell counts of 9/L. Cell surface markers on peripheral blood lymphocytes were evaluated using flow cytometry. Patients with CMV retinitis had significantly lower levels of CD8+ cells (median: 0.152 × 109/L) compared with levels for controls (median: 0.296 × 109/L, P < .001). Significant down-regulation of costimulatory molecule CD28+ and lymphocyte function-associated antigen-1 (LFA-1) expression was observed in patients versus controls (CD28+: 0.048 × 109/L vs. 0.143 × 109/L, P × .001; LFA-1: 0.238 × 109/L vs. 0.400 × 109/L, P < .001), but no significant differences were noted for NK cells. We propose that progressive loss of the CD3+CD8+ cell subset and down-regulation of CD28 and LFA-1 accessory molecules are associated with an increased risk of CMV retinitis in HIV-infected patients.Keywords
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