Loss of heterozygosity of the oestrogen receptor gene in breast cancer
Open Access
- 1 March 1995
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 71 (3) , 448-450
- https://doi.org/10.1038/bjc.1995.91
Abstract
DNA from 67 primary breast carcinoma biopsies has been examined for loss of heterozygosity (LOH) using the microsatellite (TA)n repeat marker positioned 1 kb upstream of the oestrogen receptor (ER) gene. Forty-seven (70.1%) of the cases were informative; nine of these (19.1%) were positive for LOH. In three of the nine cases, there was total loss, and in the other six cases there was a marked reduction in the intensity of signal from one allele. LOH correlated weakly with histological grade and age, but not with ER status. This result suggests that LOH of the ER gene does not have an important role in the lack of ER function in breast cancer tissues.Keywords
This publication has 22 references indexed in Scilit:
- Localization of the Estrogen Receptor Locus (ESR) to Chromosome 6q25.1 by FISH and a Simple Post-FISH Banding TechniqueGenomics, 1993
- Microsatellite polymorphisms and the genetic linkage map of the human genomeCurrent Opinion in Genetics & Development, 1993
- Loss of heterozygosity at chromosome 17p is associated with HER‐2 amplification and lack of nodal involvement in breast cancerInternational Journal of Cancer, 1993
- Dinucleotide repeat polymorphism in the human estrogen receptor (ESR) geneHuman Molecular Genetics, 1992
- Heterogeneity for Allelic Loss in Human Breast CancerJNCI Journal of the National Cancer Institute, 1992
- Genetic alterations of the tumour suppressor gene regions 3p, 11p, 13q, 17p, and 17q in human breast carcinomasGenes, Chromosomes and Cancer, 1992
- pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long‐term follow‐upHistopathology, 1991
- Prognostic factors for recurrence and survival in axillary node-negative breast cancerJournal of Steroid Biochemistry, 1989
- Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA PolymeraseScience, 1988
- Estrogen and progesterone receptors: Correlation of response rates, site and timing of receptor analysisBreast Cancer Research and Treatment, 1982