Diazoxide-induced Benin Release in Diagnosis of Remediable Renovascular Hypertension*

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Abstract
In hypertensive patients with unilateral renal artery stenosis, i.v. diazoxide increased renal vein renin activity more on the involved side than on the contralateral side, whereas, in a group with predominantly unilateral renal parenchymal disease, the increase in renal vein renin was similar for both kidneys. In patients with bilateral renal artery stenosis, the use of diazoxide was helpful in lateralizing the dominant ischemic lesion. Diazoxide administration appears to be a safe, rapid and convenient method of increasing the sensitivity of the renal vein renin test used in predicting the outcome of surgical treatment of renovascular hypertension.