Human glutamine: fructose-6-phosphate amidotransferase: characterization of mRNA and chromosomal assignment to 2p13
- 1 July 1995
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 96 (1) , 99-101
- https://doi.org/10.1007/bf00214194
Abstract
It has been previously shown that some toxic effects of high concentrations of glucose are mediated by the hexosamine biosynthesis pathway and its rate-limiting enzyme glutamine:fructose-6-phosphate amidotransferase (GFA). We have used the cloned human GFA cDNA to study the chromosomal localization of the gene and tissue distribution of mRNA. The human GFA gene is on chromosome 2, band p13 as determined by fluorescence in situ hybridization. An 8-kb species of GFA mRNA was detected in all rat tissues tested with relatively high expression in testis and smooth muscle; a unique 3-kb mRNA species was found only in testis.Keywords
This publication has 11 references indexed in Scilit:
- The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes MellitusNew England Journal of Medicine, 1993
- Regulation of Insulin-Stimulated Glycogen Synthase Activity by Overexpression of Glutamine: Fructose-6-Phosphate Amidotransferase in Rat-1 FibroblastsDiabetes, 1993
- Glucose regulation of transforming growth factor-alpha expression is mediated by products of the hexosamine biosynthesis pathway.Molecular Endocrinology, 1993
- Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase.Journal of Biological Chemistry, 1992
- Glucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cells.Proceedings of the National Academy of Sciences, 1992
- Fructose transporter in human spermatozoa and small intestine is GLUT5.Journal of Biological Chemistry, 1992
- Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance.Journal of Biological Chemistry, 1991
- Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: identification of 11q23 translocation breakpoints with a yeast artificial chromosome.Proceedings of the National Academy of Sciences, 1990