Cerebrospinal fluid cytology after subarachnoid hemorrhage

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Abstract
A method is described which was capable of detecting subarachnoid hemorrhage (SAH) up to 15-17 wk after its occurrence. The episode of SAH was confirmed by bloody and/or xanthochromic CSF at the time of SAH onset. In this study, 47 samples of lumbar CSF from diagnostically confirmed SAH patients were used. The CSF cells were collected onto slides and stained with May-Gruenwald-Giemsa or Perl''s reagent. Fe-positive cells were detected at 1 wk, increased by 4-6 wk to 8.5% of total nucleated cells, and decreased to 1% by 15-17 wk. All 27 samples obtained at 2-9 wk after SAH showed Fe-positive cells. No Fe-positive cells (false-negative samples) were noted in 25% (1 or 4) of samples obtained during the 1st wk, and in 33% (1 of 3) of samples obtained 10-12 wk and 15-17 wk after SAH. Of the total samples (37) obtained within 17 wk after SAH, 8.1% (3 of 37) were false negative. No Fe-positive cells were detected in samples obtained later than 21 wk after the SAH episode (10 samples).

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