New roles for an old enzyme: Na,K‐ATPase emerges as an interesting drug target
Top Cited Papers
- 3 January 2007
- journal article
- review article
- Published by Wiley in Journal of Internal Medicine
- Vol. 261 (1) , 44-52
- https://doi.org/10.1111/j.1365-2796.2006.01745.x
Abstract
Na,K-ATPase (NKA) is well known for its role as a maintainer of electrolyte and fluid balance in cells, organs and whole body. Exciting new findings have revealed additional fundamental roles for NKA as a signal transducer and modulator of growth, apoptosis, cell adhesion and motility. The signal transduction function can be triggered by the binding of ouabain, the mammalian analogue of digitalis to NKA. The catalytic subunit of NKA exists in different forms and mutations in two of the forms that are expressed in brain can give rise to migraine, epilepsy and Parkinsonism-like symptoms. This review will present these new aspects of NKA and their clinical implications.Keywords
This publication has 45 references indexed in Scilit:
- Contacts and cooperation between cells depend on the hormone ouabainProceedings of the National Academy of Sciences, 2006
- Low Doses of Ouabain Protect from Serum Deprivation–Triggered Apoptosis and Stimulate Kidney Cell Proliferation via Activation of NF-κBJournal of the American Society of Nephrology, 2006
- α3Na+/K+-ATPase Is a Neuronal Receptor for AgrinCell, 2006
- Structural insights into the regulatory mechanism of IP3 receptorBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2004
- Malfunction of Respiratory-Related Neuronal Activity in Na+, K+-ATPase α2 Subunit-Deficient Mice Is Attributable to Abnormal Cl-Homeostasis in Brainstem NeuronsJournal of Neuroscience, 2004
- The Identification of the Sodium PumpBioscience Reports, 2004
- Mutations in the Na+/K+-ATPase α3 Gene ATP1A3 Are Associated with Rapid-Onset Dystonia ParkinsonismNeuron, 2004
- Novel mutations in the Na+, K+‐ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsionsAnnals of Neurology, 2003
- Calcium signalling: dynamics, homeostasis and remodellingNature Reviews Molecular Cell Biology, 2003
- Mutation of the Protein Kinase C Phosphorylation Site on Rat α1 Na+,K+-ATPase Alters Regulation of Intracellular Na+ and pH and Influences Cell Shape and AdhesivenessPublished by Elsevier ,1997