A One-Pot Approach to Neoglycopeptides using Orthogonal Native Chemical Ligation and Click Chemistry
- 20 October 2009
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 11 (22) , 5270-5273
- https://doi.org/10.1021/ol902131n
Abstract
The powerful combination of native chemical ligation and click chemistry has been used to affect a one-pot synthesis of neoglycopeptides from propargyl-containing peptides using GalNAc-N3 as the glycan component. A versatile chemical toolkit for the fully convergent synthesis of neoglycoproteins using click chemistry, native chemical ligation, and kinetically controlled ligation is thus demonstrated.Keywords
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