Skin fibroblasts from humans predisposed to colon cancer are not abnormally sensitive to DNA damaging agents
- 1 May 1983
- journal article
- Published by Wiley in Cell Biology International Reports
- Vol. 7 (5) , 369-375
- https://doi.org/10.1016/0309-1651(83)90077-2
Abstract
We report here that skin fibroblasts from individuals with hereditary adenomatosis of the colon and rectum (ACR), an autosomal dominant trait, were not abnormally sensitive to x-rays, UV-light or MNNG. ACR cells were also competent in restoring x-rays and UV-light induced damage of SV40 T-antigen expression following infection of these cells by the irradiated virus. We concluded, therefore, that sensitivity to x-rays, UV-light and MNNG can not be used to identify gene-carriers dominantly predisposed to colon cancer.Keywords
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