Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum
- 1 April 1984
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 308 (5960) , 613-617
- https://doi.org/10.1038/308613a0
Abstract
The nucleotide sequence of a 4.8-kilobase mRNA for hamster 3-hydroxy-3-methylglutaryl CoA reductase, the endoplasmic reticulum enzyme that controls cholesterol biosynthesis, shows that it is a protein of 887 amino acids (MW 97,092) which contains 3 potential sites for asparagine-linked glycosylation. The reductase is a transmembrane glycoprotein, but in contrast to many other transmembrane glycoproteins, it lacks a cleavable or hydrophobic NH2-terminal signal sequence.This publication has 34 references indexed in Scilit:
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