Effects of pantetheine on cholesteryl ester synthesis in the arterial wall of rats on high cholesterol diet.

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Abstract
Increase of acyl-CoA synthesis was observed when extracts of rat arterial wall were incubated with pantetheine [D-bis-(N-pantothenyl-.beta.-aminoethyl)-disulfide]. Cholesteryl ester synthesis from palmitate in the arterial wall extract in vitro was higher with arteries from rats on a high cholesterol diet than with those from rats on a normal diet, but the synthesis was reduced in the arteries of rats on a high cholesterol diet with pantetheine. Triglyceride synthesis was higher with arterial wall extracts of rats on a high cholesterol diet than with preparations from rats on a normal diet and was not reduced with those of rats on a high cholesterol diet plus pantetheine. The value of the effects of pantetheine on lipid metabolism in the prevention of atherosclerosis is pointed out.

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