Pteroylglutamic Acid Deficiency in Mice: Hematologic and Histologic Findings.

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Abstract
A deficiency of pteroylglutamic acid in mice produces a reduction of all cellular elements of the circulating blood. In the deficient state, the bone marrow of mice shows maturation arrest with hyperplasia of immature elements and marked reduction of more adult forms. It is suggested that pteroylglutamic acid may not be necessary for the formation of the most immature blood elements, but must be present to allow maturation after these primitive elements are formed.