A rapid method for the synthesis of water-soluble platinum(II) amine and pyridine complexes
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in J. Chem. Soc., Dalton Trans.
- No. 1,p. 307-310
- https://doi.org/10.1039/dt9900000307
Abstract
Seventeen cis-[Pt(am)2(ONO2)2] complexes (am = methylamine, cycloalkylamines, substituted pyridines, aniline, or benzylamine; 2am = 2,2′-bipyridyl) were synthesized by reaction of cis-[Pt(am)2l2] with silver nitrate in acetone. The reaction was rapid (5–20 min at room temperature) with a yield of about 85%. The complexes appear to be stable in acetone with respect to isomerization. Thus, after 1 h at 25 °C acetone solutions of cis-[Pt(am)2X2](am = cyclohexylamine or 4-methylpyridine; X = I or ONO2) showed no isomerization judging by 1H n.m.r. spectroscopy of these compounds and their corresponding trans isomers.This publication has 3 references indexed in Scilit:
- Microscale syntheses of anti-tumour platinum compounds labelled with 191PtThe International Journal of Applied Radiation and Isotopes, 1985
- Platinum-Amine Compounds: Importance of the Labile and Inert Ligands for Their Pharmacological Activities Toward L1210 Leukemia Cells2JNCI Journal of the National Cancer Institute, 1983
- Studies on the antitumor activity of group VIII transition metal complexes. Part I. Platinum (II) complexesBioinorganic Chemistry, 1973