TOLERANCE AND IMMUNITY IN MICE INFECTED WITH HERPES-SIMPLEX VIRUS - SIMULTANEOUS INDUCTION OF PROTECTIVE IMMUNITY AND TOLERANCE TO DELAYED-TYPE HYPERSENSITIVITY
- 1 January 1981
- journal article
- research article
- Vol. 43 (1) , 153-159
Abstract
Unresponsiveness to delayed type hypersensitivity was induced in mice following an i.v. injection of herpes simplex virus. The principal tolerogens used were thymidine kinase-deficient virus mutants which grow poorly in vivo; UV-inactivated, and to a lesser extent, formalin-inactivated virus were also tolerogenic. The tolerance induced was specific for the virus type. Despite the tolerance to delayed hypersensitivity, anti-viral immunity is present as determined by rapid infectious virus inactivation. The mechanism of tolerance to herpes virus and the importance of these observations for viral disease pathogenesis is discussed.This publication has 17 references indexed in Scilit:
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