Effect of ethidium bromide on deoxyribonucleic acid internal motions
- 1 May 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 19 (10) , 2079-2085
- https://doi.org/10.1021/bi00551a012
Abstract
31P and 1H NMR were used to show that DNA internal motions are stopped or greatly hindered when ethidium bromide intercalates into DNA. The effect is localized to a 2 base pair long DNA region at the binding site and internal motions outside the binding site are nearly unaffected. Based upon the nearly independent behavior of bound and free DNA regions, it is concluded that in B-DNA individual base pairs experience internal motion which is independent of the motion of their neighbors.This publication has 7 references indexed in Scilit:
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