Ganglioside headgroups decrease lipid order in reconstituted phosphatidylcholine liposomes

Open Access

1 January 1985

journal article
research article
Published by Wiley in FEBS Letters

Vol. 179 (1) , 173-176
https://doi.org/10.1016/0014-5793(85)80214-3

Abstract

The effect of oligosaccharide carrying lipids on membrane fluidity has been investigated. Gangliosides GM1 and GQ1 were reconstituted into phosphatidylcholine bilayer membranes at low concentrations ( < 5 mol%). A strong fluidizing effect was observed leading to a suppression of the phase transition temperature. This was most pronounced with highly sialylated gangliosides. Ca²⁺ reverses the effect due to phase separation phenomena. We assume a hydrophilic lipid‐lipid interaction in accordance with previously studied glycoprotein‐lipid interactions.

Keywords

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