Effect of Oxandrolone on Growth and Final Height in Turner's Syndrome

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Abstract
Thirty‐two girls with Turner's syndrome aged 11.5‐16.7 years were treated with oxandrolone (0.125 mg/kg/day). The treatment period was scheduled to 2 years. Height velocity (HV) was expressed in Standard Deviation Scores (SDS), calculated by growth standards for untreated Danish Turner‐girls. For girls with initial bone age below 13 years HV increased significantly from a mean pretreatment value of ‐0.2 SDS (3.1 cm/year) to + 3.5 SDS (5.6 cm/year) in the 1st year of treatment and + 2.1 SDS (4.1 cm/year) in the 2nd year. Mean bone age velocity during treatment was 0.9 year/year. Twenty‐two girls have reached final height. Predictions of their final height were made by three different methods and compared to observed final height. A significant (p0.3). Side effects were seen in 16% of the girls.