Über den Abbau vonp-Oxyphenyl-brenztraubensäure bei Leberkranken unter dem Einfluß vonι-Ascorbinsäure und anderen Wirkstoffen
- 1 January 1954
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 298 (Jahresband) , 245-256
- https://doi.org/10.1515/bchm2.1954.298.1.245
Abstract
The effect on the metabolism of p-hydroxyphenyl pyruvic acid was determined in 11 patients with liver disease (mainly hepatitis and cirrhosis) given a number of substances. Whereas ACTH, DOCA, vitamin K, vitamin B12, folic acid, citrovorum factor, liver extract, methyl thiouracil and calcium thiosulfate had no effect, 1-ascorbic acid and d-isoascorbic acid caused increased breakdown of the test substance. In all cases the side chain was modified, and in 3 instances, the benzene ring was split. Ascorbic acid thus occupies a key position in the metabolism of tyrosine, but the mode of action of ascorbic acid remains unclarified.This publication has 1 reference indexed in Scilit: