The rate of DNA replication at the molecular, chromosomal, cellular, and intercellular levels in regenerating rat liver.

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Abstract
The rate of increase in DNA synthesis in the total liver and changes in the rate of DNA synthesis in individual cells and chromosomes could be described by an exponential equation between the onset of synthesis and the maximum rate of synthesis at 21 hr after partial hepatectomy. These exponential changes in rate at the higher organizational levels can be explained by increasing numbers of sites of DNA replication indicating that DNA synthesis at the molecular level could proceed at a linear rate of 1 x 10-16 g of DNA/min.