Hippocampal Electrical Activity and γ‐Aminobutyrate Metabolism in Brain Tissue Following Administration of Homocysteine

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Abstract
GABA concentration and the activity of glutamate decarboxylase and GABA-transaminase were measured in extracts of mouse brain before the onset and during the course of generalized seizures induced by systemic administration of homocysteine thiolactone. Whole brain GABA metabolism seems unaffected by subconvulsive and convulsive doses of homocysteine at all stages of the generalized seizure. EEG monitoring of rat brain electrical activity via hippocampal electrode implantation allowed the course of homocysteine-induced seizures to be followed and afforded a means of quantifying such seizures.