The Correlation between the Antitumor Activities and Chemical Structures of Thiocyanato Derivatives of Purines and Their Ribonucleosides
- 31 December 1967
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 16 (3) , 505-508
- https://doi.org/10.1248/cpb.16.505
Abstract
The effect of 14 thiocyanato derivatives of purines and their ribonucleosides were compared with the effects of 6-purine-thiol and 2-amino-6-purimethiol against transplanted sarcoma (NF-Sarcoma) in mice and the correlation was noted between antitumor activities and substituting position of thiocyanato group and other substituent groups on the purine ring. 6-Thiocyanatopurine, 2-amino-6-thiocyanatopurines and their ribonucleosides were demonstrated as the most active of the thiocyanato derivatives.This publication has 3 references indexed in Scilit:
- Synthetic Nucleosides and Nucleotides. I. On Synthesis and Properties of Several Thiocyanato Derivatives of Purines and Their Ribonucleosides.CHEMICAL & PHARMACEUTICAL BULLETIN, 1967
- Antitumor Activity and Structural Relationships of Purine Derivatives and Related Compounds against Neoplasms in Experimental AnimalsJournal of Medicinal Chemistry, 1964
- Potential Purine Antagonists. XXXI. The Preparation of Certain 9-Alkyl-2-amino-6-purinethiols and Related Derivatives as Antitumor AgentsJournal of Medicinal Chemistry, 1962