DETECTION OF GENETIC-VARIATION WITH RADIOACTIVE LIGANDS .4. X-LINKED, POLYMORPHIC GENETIC-VARIATION OF THYROXIN-BINDING GLOBULIN (TBG)
- 1 January 1981
- journal article
- research article
- Vol. 33 (4) , 640-648
Abstract
A genetically determined, polymorphic electrophoretic variant of thyroxin-binding .alpha.-globulin (TBG) is found in sera from populations of African and Oceanian origin, but not in Caucasians nor Orientals. The TBG polymorphism is inherited in X-linked fashion, based on data from American blacks, and provides an X-chromosome marker with a relatively high gene frequency in this ethnic group (frequency of the slow allele, TBGS, is 11%). This slow variant should prove valuable in expanding the map of the X chromosome and in linkage studies. An additional family exhibiting X-linked TBG deficiency is also described.This publication has 15 references indexed in Scilit:
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