Peptide‐mediated regulation of the allergic immune response
- 1 April 1996
- journal article
- review article
- Published by Wiley in Immunology & Cell Biology
- Vol. 74 (2) , 180-186
- https://doi.org/10.1038/icb.1996.25
Abstract
A major key to successful immunotherapy may depend on altering the qualitative nature of the immune response in allergic patients. In this review we examine how immune responses to environmental allergens are regulated, and the mechanisms used by the immune system to prevent allergic sensitization. We also discuss future prospects of using allergen-derived peptides in immunotherapy and the possibility of 'reprogramming'the immune responses by immunizing under conditions that promote Th1 responses instead of Th2 responses.Keywords
This publication has 71 references indexed in Scilit:
- Immunoprophylaxis of atopy: light at the end of the tunnel?Immunology Today, 1994
- Potential therapeutic recombinant proteins comprised of peptides containing recombined T cell epitopesMolecular Immunology, 1994
- Clinical and immunological effects of immunotherapy with alum‐absorbed grass allergoid in grass‐pollen‐induced hay feverAllergy, 1992
- Monitoring of mite Dermatophagoides farinae allergen‐specific IgG and IgG subclass distribution in patients on immunotherapyAllergy, 1992
- Predominant TH2-like Bronchoalveolar T-Lymphocyte Population in Atopic AsthmaNew England Journal of Medicine, 1992
- Functional subsets of allergen-reactive human CD4+ T cellsImmunology Today, 1991
- Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance inductionCell, 1991
- Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic miceCell, 1991
- Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunityCell, 1990
- The regulation of immune responses to dietary protein antigensImmunology Today, 1987