Angiotensin II type 1 receptor gene polymorphisms in humans: physiology and pathophysiology of the genotypes
- 1 January 2001
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Nephrology and Hypertension
- Vol. 10 (1) , 111-116
- https://doi.org/10.1097/00041552-200101000-00017
Abstract
Many studies have attempted to relate genetic variants of components of the renin-angiotensin system to complex diseases such as essential hypertension, cardiovascular disease and progressive renal failure. The angiotensin II type 1 receptor (AT1R) gene is an important example of this approach. Many polymorphisms of the AT1R gene have been identified, but the A1166→C polymorphism has been the most extensively studied. The physiological significance of this polymorphism is uncertain because of its location in the 3′-untranslated region of the gene. The present review summarizes association studies of the AT1R gene, focusing on clinical end-points and physiological responses.Keywords
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