Synergistic, additive, and antagonistic mutagenic responses to binary mixtures of benzo(a)pyrene and benzo(e)pyrene as detected by strains TA98 and TA100 in the salmonella/microsome assay
- 1 January 1981
- journal article
- research article
- Published by Wiley in Environmental Mutagenesis
- Vol. 3 (2) , 159-166
- https://doi.org/10.1002/em.2860030207
Abstract
Binary mixtures of benzo(a)pyrene (B(a)P) and benzo(e)pyrene (B(e)P) produce synergistic mutagenic (comutagenic) responses in Salmonella typhimurium strain TA98 (a frameshift detector). The optimum enhancement (25 ×) was found at B(a)P concentration of 0.3 μg/plate and B(e)P concentration of 1.5 μg/plate. The response of strain TA100 (mostly a base-substitution detector) is opposite that of TA98, showing antagonism and additivity in similar concentration ranges.Keywords
This publication has 13 references indexed in Scilit:
- Interaction between amino-α-carboline and amino-γ-carboline on mutagenicity in Salmonella typhimuriumMutation Research/Genetic Toxicology, 1979
- Synergistic effect of diethylstilbestrol on the mutagenicity of 2-acetylaminofluorene and N-hydroxy-acetylaminofluorene in the Salmonella assay systemCancer Letters, 1979
- Use of Ames test in evaluation of shale oil fractions.Environmental Health Perspectives, 1979
- Use of Ames Test in Evaluation of Shale Oil FractionsEnvironmental Health Perspectives, 1979
- Effect of the co‐carcinogen benzo[e] pyrene on microsome‐mediated chemical mutagenesis in salmonella typhimuriumEnvironmental Mutagenesis, 1979
- Comutagenic effects exerted by N-nitroso compoundsMutation Research/Genetic Toxicology, 1979
- Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.Proceedings of the National Academy of Sciences, 1975
- Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity testMutation Research/Environmental Mutagenesis and Related Subjects, 1975
- Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for DetectionProceedings of the National Academy of Sciences, 1973
- Association of Induced Frameshift Mutagenesis and DNA Replication in Escherichia coliNature New Biology, 1972