Enhanced alternation performance following septal lesions in mice.

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Abstract
Male and female B6D2F1 hybrid mice were given septal lesions (Group SEPT), cortical lesions (CORT), or served as unoperated controls (NORM). Ss were trained for food reward in a 2-lever single-alternation task. Performance of Group SEPT was significantly better than that of the control group; Groups CORT and NORM did not differ from each other. Results are incompatible with the hypothesis that septal lesions produce a simple deficit in response inhibition or sequential behavior. It is suggested that the results might be attributed to higher response rates because of septal lesion-induced enhancement of the reward value of the food. (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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