Xenobiotic Transporters: Another Protective Mechanism for Chemicals
- 1 January 2002
- journal article
- research article
- Published by SAGE Publications in International Journal of Toxicology
- Vol. 21 (1) , 7-12
- https://doi.org/10.1080/10915810252825975
Abstract
Xenobiotic transporters are responsible for the uptake of some chemicals into cells, and extremely important for the export of chemicals out of cells. A number of families of xenobiotic transporters have been cloned the last few years. Some microsomal enzyme inducers will enhance the plasma disappearance and biliary excretion of some xenobiotics that are not biotransformed in the intact animal, as well as in isolated hepatocytes. This is due to an up-regulation of xenobiotic transporters. As a result, some microsomal enzyme inducers will enhance the elimination and decrease the toxicity of some chemicals by enhanced transport.Keywords
This publication has 6 references indexed in Scilit:
- Differential Effects of Microsomal Enzyme-Inducing Chemicals on the Hepatic Expression of Rat Organic Anion Transporters, Oatp1 and Oatp2Hepatology, 2001
- Multidrug resistance: molecular mechanisms and clinical relevanceCancer Chemotherapy and Pharmacology, 1997
- Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugsPublished by Elsevier ,1994
- BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTERAnnual Review of Biochemistry, 1993
- THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCEAnnual Review of Biochemistry, 1989
- Plasma disappearance and biliary excretion of sulfobromophthalein and phenol-3,6-dibromphthalein disulfonate after microsomal enzyme inductionBiochemical Pharmacology, 1970