Convenient Syntheses of Nabumetone
- 1 January 1989
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1989 (11) , 869-870
- https://doi.org/10.1055/s-1989-27417
Abstract
Two novel and convergent one- and two-step syntheses of 4-(6′-methoxy-2′-naphthyl) -2-butanone (nabumetone, 6) via palladium-catalyzed coupling of 2-halo-6-methoxynaphthalene (1) with 3-buten-2-ol (2) and 3-buten-2-one (3) are described. The product is obtained in 60-92% yield.Keywords
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