Grapefruit Juice Activates P-Glycoprotein-Mediated Drug Transport
- 1 January 1999
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 16 (4) , 478-485
- https://doi.org/10.1023/a:1011902625609
Abstract
Purpose. Grapefruit juice (GJ) is known to increase the oral bioavailability of many CYP3A-substrates by inhibiting intestinal phase-I metabolism. However, the magnitude of AUC increase is often...Keywords
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