Routine Immunohistology in Renal Diseases

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Abstract
In 1907 it was suggested (1) that certain renal diseases may be caused by an immune reaction involving the glomerulus. This hypothesis has recently received renewed support. In 1951 we demonstrated the presence of antibodies against human kidney tissue emulsion in a group of patients with chronic glomerulonephritis (2). Studies revealing a lowering of serum complement activity in patients with acute glomerulonephritis, systemic lupus erythematosus, and nephrosis (3-7) lend added support to the possibility that an immune mechanism may be responsible for these diseases. Using an immunofluorescent technique on autopsy material from patients with glomerulonephritis, Mellors and Ortega (8) have

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