A cluster of mutations determining erythromycin resistance in Bacillus subtilis

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Abstract
Forty erythromycin-resistant mutants of Bacillus subtilis strain 168 were isolated as spontaneous mutants or after induction with 2-aminopurine. They showed different levels of resistance and six of these mutants were studied genetically using transformation reactions. Recombination of some pairs of mutations has a synergistic effect on resistance. All six mutants are clustered on the B. subtilis chromosome between the genes str conferring streptomycin resistance and pur B determining purine biosynthesis. Some mutations overlap at the same site. The genetic order of these ery mutations with respect to one another and a streptomycin-resistant mutation str has been determined.

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