The analysis of dose‐response curves‐a practical approach.
Open Access
- 1 February 1987
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 23 (2) , 199-205
- https://doi.org/10.1111/j.1365-2125.1987.tb03030.x
Abstract
The rationale for the objective assessment of dose-response curves (DRCs) is presented. Using data derived from isoprenaline/heart rate responses studies, two new statistical methods of objectively defining the terminal linear segment of an incomplete DRC are presented. Using data derived from phenylephrine/diastolic blood pressure response studies, the parallel shift quadratic model of Sumner et al. (1982) has been extended to include a measure of the suitability of the quadratic model for each individual data set using the Akaike information criterion. A parallel shift Emax model is proposed for complete DRCs.This publication has 5 references indexed in Scilit:
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