Clinical Interpretation of the One-Stage Prothrombin Time

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Abstract
In the original one-stage prothrombin time, the anticoagulant is sodium oxalate, and the thromboplastin is an extract of acetone-dehydrated rabbit brain. This reagent has constant potency, is stable, and is devoid of prothrombin, factors V, VII and X. The prothrombin time becomes prolonged from a deficiency of prothrombin, factors V, VII or X. A deficiency of 2 or more of these factors can occur but the effect is not additive. Aged serum is rich in factors VII and X. When added to plasma it will correct any deficiency of these factors, but not a true lack of prothrombin. Dicumarol causes a depression of factor VII and eventually of prothrombin. By means of the basic one-stage test, factor VII is quantitatively determined, and by adding aged serum, the corrected prothrombin time measures prothrombin.

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