The haemodynamic responses to incremental doses of intravenous nitroglycerin in left ventricular failure

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Abstract
Summary The effects of incremental dose infusions of nitroglycerin, 10–160 μg/min, on pulmonary capillary wedge pressure and other haemodynamic variables have been studied in patients with left ventricular failure. Intravenous (IV) nitroglycerin caused a dose-related improvement in myocardial performance, with significant reductions in the raised pulmonary capillary wedge pressure and systemic vascular resistance. At the lowest dose of infusion only the venodilator action of nitroglycerin was apparent. From 40–160 μg/min the associated arteriolar dilatation was associated with a consistent improvement in myocardial performance.