Inhibition of Peptidoglycan Synthesis by the Antibiotic Diumycin A
- 1 December 1972
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 2 (6) , 485-491
- https://doi.org/10.1128/aac.2.6.485
Abstract
Diumycin A, a new antibiotic, was found to inhibit cell wall synthesis by Staphylococcus aureus , a phenomenon accompanied by accumulation of uridine-5′-diphosphate- N -acetyl-muramyl-pentapeptide. The antibiotic inhibited in vitro peptidoglycan synthesis by particulate preparations of Bacillus stearothermophilus and Escherichia coli by preventing the utilization of N -acetyl-glucosamine- N -acetyl-muramyl-pentapeptide. In contrast to vancomycin, the antibiotics diumycin, prasinomycin, moenomycin, 11.837 RP, and enduracidin do not inhibit particulate d -alanine carboxypeptidase.Keywords
This publication has 23 references indexed in Scilit:
- Mechanism of Action of Bacitracin: Complexation with Metal Ion and C 55 -Isoprenyl PyrophosphateProceedings of the National Academy of Sciences, 1971
- A simple method for following the fate of alanine-containing components in murein synthesis inEscherichia coliAntonie van Leeuwenhoek, 1971
- Modifications of the acyl-d-alanyl-d-alanine terminus affecting complex-formation with vancomycinBiochemical Journal, 1971
- Streptomyces albus G DD carboxypeptidase mechanism of action of penicillin, vancomycin, and ristocetinBiochemistry, 1970
- Phosphonomycin, a New Antibiotic Produced by Strains of StreptomycesScience, 1969
- BACITRACIN: AN INHIBITOR OF THE DEPHOSPHORYLATION OF LIPID PYROPHOSPHATE, AN INTERMEDIATE IN THE BIOSYNTHESIS OF THE PEPTIDOGLYCAN OF BACTERIAL CELL WALLSProceedings of the National Academy of Sciences, 1967
- The Prasinomycins: Antibiotics containing PhosphorusNature, 1967
- Effect of penicillin on cell wall mucopeptide synthesis in a Escherichia coli particulate systemBiochemical and Biophysical Research Communications, 1966
- Biosynthesis of the peptidoglycan of bacterial cell wallsArchives of Biochemistry and Biophysics, 1966
- Penicillin: its basic site of action as an inhibitor of a peptide cross-linking reaction in cell wall mucopeptide synthesis.Proceedings of the National Academy of Sciences, 1965