Wild-Type Huntingtin Reduces the Cellular Toxicity of Mutant Huntingtin In Vivo
- 1 February 2001
- journal article
- Published by Elsevier in American Journal of Human Genetics
- Vol. 68 (2) , 313-324
- https://doi.org/10.1086/318207
Abstract
No abstract availableKeywords
This publication has 35 references indexed in Scilit:
- Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in miceNature Genetics, 2000
- Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicityNature Genetics, 2000
- Inhibiting Caspase Cleavage of Huntingtin Reduces Toxicity and Aggregate Formation in Neuronal and Nonneuronal CellsJournal of Biological Chemistry, 2000
- Wild-Type Huntingtin Protects from Apoptosis Upstream of Caspase-3Journal of Neuroscience, 2000
- Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in miceHuman Molecular Genetics, 2000
- Huntingtin Is Ubiquitinated and Interacts with a Specific Ubiquitin-conjugating EnzymeJournal of Biological Chemistry, 1996
- Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin.Proceedings of the National Academy of Sciences, 1996
- Sequence of the murine Huntington dusease gene: evidence for conservation, and polymorphism in a triplet (CCG) repeat alternate splicingHuman Molecular Genetics, 1994
- The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's diseaseNature Genetics, 1993
- A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomesCell, 1993