Formation of 5- and 6-Aminocytosine Nucleosides and Nucleotides from the Corresponding 5-Bromocytosine Derivatives: Synthesis and Reaction Mechanism
- 3 January 1983
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 2 (2) , 175-187
- https://doi.org/10.1080/07328318308081257
Abstract
An improved method for the synthesis of 5-aminocytidine, 5-amino-2''-deoxycytidine and their 5''-monophosphates from the corresponding 5-bromo pyrimidines, using liquid ammonia, is described. [Modifications of cytosine nucleosides and nucleotides have led to a variety of useful antimetabolites and enzyme inhibitors]. The respective 6-aminocytosine derivatives, minor products of the amination reaction, were isolated and characterized. A plausible mechanism is proposed to account for the formation of both 5- and 6-substituted products.This publication has 14 references indexed in Scilit:
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