Chronic Effect of .BETA.-Adrenoceptor Blockade on Plasma Levels of Brain Natriuretic Peptide during Exercise in Essential Hypertension.
- 1 January 1996
- journal article
- clinical trial
- Published by Japanese Society of Hypertension in Hypertension Research
- Vol. 19 (4) , 239-245
- https://doi.org/10.1291/hypres.19.239
Abstract
Many factors have been reported to stimulate the release of brain natriuretic peptide (BNP) as well as atrial natriuretic peptide (ANP). In hypertensive patients, however, little is known about whether these factors differ from those in normotensive subjects or if they are influenced by antihypertensive treatment. We measured the plasma concentrations of BNP and ANP in 12 hypertensive patients and examined the chronic effects of β-adrenoceptor blockade on BNP secretion during exercise with a bicycle ergometer. The exercise raised both plasma BNP and ANP with concomitant increases in systolic blood pressure, heart rate (HR) and plasma norepinephrine (NE) and epinephrine (Epi) before and after treatment. Before treatment, the changes in ANP and BNP correlated with that in HR (pHypertens Res 1996; 19: 239-245)Keywords
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