The Relation of Childhood Infection to the Development of Tuberculosis in Early Adult Life

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Abstract
Observation during adolescence and early adult life was given 982 individuals who had had a positive tuberculin reaction during childhood. Accurate information concerning the occurrence of household contact with sputum-positive tuberculosis was available. The mean annual morbidity rate was 0.33% in the white group, and 1.21% in the colored group. The mean annual morbidity rate was 0.21% in white [male][male] as compared to 0.44% in white [female][female], and 0.54% in colored [male][male] as compared to 1.69% in colored [female][female]. The mean annual morbidity rate was 0.1% in white persons not having household contact after childhoo.d as compared to 2% in white persons having household exposure during adolescence and adult life; the corresponding rates for the colored group were 0.98% and 3.62%. The morbidity rate in persons who had roentgenological evidence of primary-type tuberculosis was not, in the absence of household contact in adult life, significantly higher than the rate in persons with negative films. The rate of 0.33% observed in white persons, few of whom had preventorium care, was not appreciably higher than the rate calculated from comparable data reported in persons discharged from preven-toria.

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