Effect of Tetraethylammonium Chloride on Cardiac Muscle Fiber Responses.

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Abstract
Fe fluxes and relative concentrations are known to affect action potential durations and the stability of membranes. Ca ion is known to have a stabilizing action. Numerous compounds affect the characteristically long action potentials of ventricular tissues. Some metabolic inhibitors shorten the action potential and cause development of spontaneous activity while other compounds have an opposite effect. It is felt that they directly or indirectly modify ion transport and balances. TEA, though initially prolonging action potentials, eventually creates an instability. The best evidence available indicates this is due to an effect on Ca++ permeability.

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