Diastereomer Method for Determining ee by 1H NMR and/or MS Spectrometry with Complete Removal of the Kinetic Resolution Effect
- 10 July 2002
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (16) , 2699-2702
- https://doi.org/10.1021/ol026217a
Abstract
Using chiral auxiliaries, 2-methoxy-2-(1-naphthyl)propionic acid (MαNP acid) (S)-(+)-1 and its deuterium-labeled enantiomer (R)-(−)-1-dn (n = 3 or 6), we have developed a new diastereomer method for determining enantiomeric excess (% ee) of chiral alcohols by 1H NMR and/or MS spectrometry, where the kinetic resolution effect is completely excluded. The data of % ee determined by this method agree well with those calculated by weight, the average error being ca. ±1.08% ee.Keywords
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