Marrow Storage Techniques: A Clinical Comparison of Refrigeration versus Cryopreservation
- 1 January 1991
- journal article
- research article
- Published by S. Karger AG in Acta Haematologica
- Vol. 85 (4) , 173-178
- https://doi.org/10.1159/000204886
Abstract
Fifty-three patients were evaluated for a comparison of the efficacy, safety, and cost efficiency of bone marrow (BM) transplanted after either refrigeration or cryopreservation. Thirty-eight patients had BM stored at 4 °C for an average of 3 days and 15 patients had cryopreserved BM stored for an average of 56 days. The average number of cells harvested was 3.8 × 108/kg. The time to WBC recovery > 1 × 109/l was 17 days refrigerated and 23 days for cryopreserved BM. The time to platelet recovery > 20 × 109/l was 24 days for refrigeration storage and 51 days for cryopreserved BM. Four of 38 patients with refrigerated vs. 4/15 patients with cryopreserved BM experienced delayed engraftment (p < 0.05). Refrigeration storage requires no special equipment, is cheaper than and presents a safe and viable alternative to cryopreserved BM in reconstituting hemopoiesis following high-dose chemo-radiotherapy.Keywords
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