POSTOVULATORY DECREASE IN ESTROGEN PRODUCTION IS CAUSED BY THE DIMINISHED SUPPLY OF AROMATIZABLE ANDROGEN TO OVARIAN AROMATASE
- 1 December 1980
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 107 (6) , 2115-2116
- https://doi.org/10.1210/endo-107-6-2115
Abstract
After administration of testosterone to immature rats which had ovulated after treatment with PMSG and hCG, a significant increase in ovarian content of estradiol–17β was observed. Together with our previous result on the immediate decrease in ovarian 17α-hydroxylase and C-17-C-20 lyase after PMSG and hCG treatment, it is concluded that the drastic decrease in serum estradiol-173 after ovulation is caused by a shortage of supply of aromatizable androgen(s) to the ovarian aromatase, due to diminished activities of the above two enzymes.Keywords
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