Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4 + T Cells
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- 26 February 2010
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 327 (5969) , 1098-1102
- https://doi.org/10.1126/science.1178334
Abstract
Critical Mediators: Helper T cells are the immune system's ringmasters, having a multiplicity of functions that mediate the body's immune responses to infections. Depending on the type of infection, CD4 + helper T cells respond by secreting specific patterns of cytokines, which provide important cues to other subsets of immune cells. CD4 + T cells with distinct cytokine profiles have been viewed classically as separate lineages; however, there is mounting evidence that these cells may not be terminally differentiated but are in fact quite plastic. O'Shea and Paul (p. 1098 ) review the current understanding of CD4 + T cell subset differentiation and the underlying mechanisms that drive cell-lineage commitment.Keywords
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