Single Dose Response Curves of Normal CellsIn Situ

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Abstract
Analysis of data on the response of normal tissues (from mouse and rat skin, lung, spinal cord, intestine, testis) to single and multifractionated irradiation schedules revealed the characteristics of the single dose survival curves of target cells responsible for skin, lung and spinal cord reactions, and of stem cells of colonic, jejunal, gastric mucosae and testis exposed in situ to relatively low doses of X- or .gamma.-rays. The single dose survival curves of these cells seem to be complex (unlike those of cells studied in vitro), that is, simply exponential in the initial portion up to approximately 250 rad, and downward-bending thereafter in a curve which includes 1 or 2 linear portions on a semilogarithmic scale.