GENETIC-CONTROL OF SENSITIVITY TO MOLONEY LEUKEMIA-VIRUS IN MICE .2. MAPPING OF 3 RESISTANT GENES WITHIN THE H-2-COMPLEX

  • 1 January 1979
    • journal article
    • research article
    • Vol. 123  (4) , 1806-1812
Abstract
The level of viremia and the appearance of leukemias were studied after inoculation with Moloney leukemia virus (M-MuLV) in different H-2 congenic strains of mice. The viremia was regularly measured on individual mice with a radioimmunoassay of the major internal virion component p30. Three genes within the major histocompatibility complex controlled the level of circulating virus. Two, Rmv.1 and Rmv.2, appear to be located in the I region, respectively, in the IA, and the IC-S or G regions. The 3rd gene, Rmv.3, was mapped to the D end of the complex in the D or T region. Crosses between resistant and sensitive strains demonstrated that the H-2 associated resistance was inherited as a dominant or semi-dominant Mendelian trait. Rmv.1, Rmv.2 and Rmv.3 complemented for resistance in trans when the hybrids between sensitive strains were examined. A good correlation was found between viremia and the appearance of leukemias, the most viremic strains being also the most leukemic. Nevertheless, additional non-H-2 genes must control viremia and/or the appearance of leukemia since, despite high levels of viremia, some sensitive strains do not become leukemic.