Evaluation of a Simplified Technic for the Measurement of Aldosterone in Human Urine

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Abstract
A simple and highly reproducible method for the measurement of urinary aldosterone is described. This method, which is a modification of that previously described by Bravo and Travis,2 appears far simpler and more convenient than other existing procedures and is suitable for use in a clinical laboratory. Evidence for specificity is presented. It is sensitive enough for clinical purposes. Important evidence for its validity and reliability has accrued from studies in a variety of clinical situations in which the values for urinary aldosterone are in close agreement with those reported by various groups of investigators using specific methods. Although it may seem outmoded in view of recent developments in radioimmunoassay technics,1,7 it circumvents most of the potential errors and difficulties inherent in radioimmunoassay methods and may still achieve wide applicability in a clinical laboratory experienced in gas-liquid chromatography.

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